You may never need to know how to access safe mode on macOS, but I encourage you to do so as you never know what issue will pop up that will require you to understand how to utilize the feature. Please note that you will not be able to mount the EFI System Partition while in Safe Boot mode due to the boot arguments being active.
Clover Bootloader
Press the space bar after selecting the partition that contains macOS.
OpenCore Bootloader
Press the Shift + Enter combination after selecting the partition that contains macOS.