As a technician, if you hear end-users complain that they cannot start Microsoft Outlook, check to see if the users can log into the Outlook Web Access client which is used to communicate with the Exchange Server. If they cannot access the OWA, it would be an indication to you that your Network Administrators is in the process of maintaining the Exchange Server and it will take approximately 15 to 60 minutes for all to return to normal.
If they can access the Outlook Web Access or Outlook Web App, try and recreate their email profile again (from the Control Panel in Windows) without destroying the current profile. If that then works, look in the old profile and add the Personal folders and any additional mailboxes. Before you leave the user, ask them to print an email (not the attachment) as a small percent of user tend to say that they can’t print from Outlook after having the primary issue.