One thing that drives me crazy each week is seeing a 49.0665 Error message on an HP printer. It’s always the same model (HP LaserJet 9050n) and it means someone is printing a document (.DOC, .PDF, .XLS) that the printer is unable to handle.
The quick fix for this is to turn off the printer and determine if the printer is added to user’s computer via the IP Address or through a Print Server.
Via IP Address
If users are set to print via the IP address, you have to go to everyone and see if their print job is the earliest and kill it off and any duplicates they print when they did not see it on the printer. You can try to kill off the job at the printer (with the trays open) but the signal is faster then you and will lock up the printer over and over and over.
Now that printing is restored, add the printer to a Print Server and connect the users through it. Should the issue happen again, when the users call to complain, use Remote Desktop and access the print server and kill of the job in the print queue.
If users are set to print through a print server, consider yourself fortunate and kill off the very first print job in the que. 80% of the time, the job that you killed off will be a multiple page document in .PDF or .DOC. and happens due to the number of fonts in the document.